IndraLab

Statements

USP13 activates mutated EGFR. 5 / 5
| 5
reach
"37 USP13 is likely to stabilize mutant EGFR in a ubiquitinated state, and inhibition of USP13 destabilizes mutant EGFR and abrogates signaling of mutant EGFR in lung cancer cells."
33210294
reach
"Targeting USP13 mediated drug tolerance increases the efficacy of EGFR inhibition of mutant EGFR in non small cell lung cancer."
33210294
reach
"We found that USP13 inhibits mutant EGFR degradation by a process that leads to the accumulation of ubiquitinated (K48 and K63) EGFR, which is bound to c-Cbl and USP13."
33210294
reach
"Combined targeting of USP13 and EGFR strongly reduces the viability of EGFR mutant lung cancer cells in vitro and in vivo while sparing non malignant (EGFR wild-type) lung epithelial cells."
33210294
reach
"Targeting USP13 increased the sensitivity of EGFRm NSCLC cells to EGFR inhibition with small molecules in vitro and in vivo, suggesting that USP13 is a strong mutant EGFR-specific co-target that could improve the treatment efficacy of EGFR-targeted therapies."
37609474