IndraLab

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MYB activates CYLD. 9 / 9
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"Notably, we also show that MYB drives the proliferation of CYLD defective cylindroma cells."
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"Our experiment supported that silenced MYB suppressed OTSCC malignancy by inhibiting miR-130a and activating CYLD."
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"Overexpression of MYB is known to drive proliferation of CYLD defective cylindroma cells, and molecular heterogeneity in the pathogenesis of sporadic and inherited cutaneous cylindromas appears to converge on MYB activation [XREF_BIBR]."
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"CYLD defective cylindroma cells were treated with MYB siRNAs for 72h, after which total cellular protein was prepared by lysing cells in RIPA lysis buffer (Millipore) supplemented with complete Mini Protease Inhibitors (Roche)."
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"MYB Knockdown Activates CYLD to Suppress OTSCC in vivo by Downregulating miR-130a Expression."
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"CYLD defective cylindroma cells were treated with MYB siRNAs for 6 consecutive days, after which cell proliferation was assayed using Alamar Blue Reagent (Thermo Fisher Scientific) and a VICTOR-3 multilabel reader (Perkin-Elmer), according to instructions supplied by the manufacturers."
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"This resulted in a significant inhibition of MYB target genes and proliferation of cylindroma cells from three independent tumours, suggesting that MYB activation drives the growth of CYLD defective cylindromas and potentially also the growth of MYB-NFIB-positive sporadic cylindromas."
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"MYB promotes the proliferation of CYLD defective cylindroma cells."
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"CYLD defective cylindroma cells were treated with MYB siRNAs for 48h before total RNA was extracted using an RNeasy Micro-kit (Qiagen)."
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