IndraLab

Statements

COPS5 activates SOX9. 4 / 4
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"Moreover, in Jab1 knockout mutants, Sox9 expression and activity was severely compromised, suggesting Jab1 positively regulates Sox9 in early growth plate development."
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"Notably, Jab1 by itself did not activate Sox9 reporter in 10T1/2 cells (XREF_FIG)."
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"Jab1 likely promotes Sox9 and BMP signaling activity during early limb development."
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"Additionally, Jab1 can increase Sox9 transcriptional activity in 10T1/2 cells (XREF_FIG)."
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