IndraLab

Statements

CLOCK activates USP2. 3 / 3
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"However, the free running period (tau), a key intrinsic characteristic of the central circadian clock, was significantly increased in Usp2 KO mice (XREF_FIG; XREF_TABLE) (also reproduced in an additional group of mice, data not shown), suggesting the involvement of USP2 in the molecular clockwork."
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"This suggests a scenario in USP2 -/- mice in which increased turnover of BMAL1 coincides with increased CLOCK and BMAL1 driven gene expression in the USP2 -/- SCN."
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"The circadian rhythm of Usp2 is blunted in Clock mutant and Bmal1 KO mice, and the Usp2 promoter is activated by CLOCK and BMAL1, indicating that Usp2 is a direct target of these transcription factors."
25147498