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SLC5A11 inhibits KCNQ1. 2 / 2

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"Intriguingly, we also found that KCNQ1 and SMIT2 functionally interact, and that SMIT2 inhibits KCNQ1 activity, but we do not yet know the mechanistic basis for these effects either."

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"R231A-KCNQ1 also inhibited activity of SMIT2, a SMIT1 related myo-inositol transporter encoded by SLC5A11, while SMIT2 inhibited KCNQ1 activity, when the two were co-expressed in Xenopus oocytes [XREF_BIBR]."

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SLC5A11 inhibits KCNQ1. 2 / 2

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