IndraLab

Statements

TNF activates SCN5A. 2 / 2
1 | 1
signor
"TNF-α increases Na(+) currents by accelerating the channel activation as well as increasing the expression of VGSCs in a mechanism dependent upon NF-κB and p38 MAPK signal pathways in CNS neurons. TNF-α increased Na(+) currents by accelerating the activation of VGSCs. The threshold for action potential (AP) was decreased and firing rate were increased. VGSCs were up-regulated at both the mRNA and protein levels."
26112872
reach
"Notably, amplification of TTX-R and NaV1.8 currents induced by TNF-alpha was attenuated in DRG neurons with pre-incubation of respective inhibitors of intracellular signal pathways p38-MAPK, JNK and ERK."
32101460