IndraLab

Statements

USP22 binds FOXO1. 7 / 7
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sparser
"The endogenous USP22 interaction with FOXO1 was further confirmed in MDA-MB-231 cells ( xref )."
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sparser
"Further analysis of FOXO1 interactions with USP22 truncated mutants revealed that the zinc finger–containing N terminus of USP22 mediates its interaction with FOXO1 ( xref )."
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sparser
"Stimulation with EPI markedly increased USP22 interaction with FOXO1 in breast cancer cells ( xref )."
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sparser
"EPI stimulation, which induced USP22 protein expression and promoted USP22-FOXO1 interaction, markedly inhibited FOXO1 polyubiquitination in USP22 WT cancer cells, and targeted USP22 deletion resulted in a significant increase in FOXO1 ubiquitination and reduced FOXO1 protein expression even with EPI stimulation ( xref )."
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reach
"The endogenous USP22 interaction with FOXO1 was further confirmed in MDA-MB-231 cells (Fig. 4L)."
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reach
"Further analysis of FOXO1 interactions with USP22 truncated mutants revealed that the zinc finger–containing N terminus of USP22 mediates its interaction with FOXO1 (Fig. 4K)."
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sparser
"To define USP22 functions as a possible FOXO1-specific deubiquitinating enzyme, we first determined if USP22 interacts with FOXO1."
39151008