IndraLab

Statements

VCPIP1 activates SPRTN. 4 / 4
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"Huang et al. reported that knockdown of VCPIP1 prevented SPRTN chromatin localization upon formaldehyde treatment, in agreement with previous reports that monoubiquitinated SPRTN is excluded from the chromatin (Stingele et al., 2016; Huang et al., 2020)."
35782873
eidos
"Knockdown of VCPIP1 greatly reduced the interaction between SPRTN and PCAF / GCN5 in the presence of DPCs ( Figure S4H ) , suggesting that VCPIP1 is required to bring acetyltransferases to SPRTN in a DPC-dependent manner ."
32649882
reach
"Thus, the identification of VCPIP1 as a dual promoter of SPRTN deubiquitination and acetylation may mean that knockdown of VCPIP1 is dysregulating SPRTN at multiple steps, and that SPRTN acetylation may be the signal for its chromatin retention upon DPC induction rather than deubiquitination (Table 1)."
35782873
reach
"However, VCIP135 was reported to function without the assistance of p97 in the activation of SPRTN, a specialized DNA-dependent metalloprotease (12)."
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