IndraLab

Statements

Hydrogen peroxide inhibits NFKBIA. 2 / 2
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"Catalase 1 kU/ml inhibited NF-kappaB activation by TNF-alpha; exogenous hydrogen peroxide 200 microM activated NF-kappaB and stimulated I-kappaBalpha degradation."
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"Oxidative stress , via its formation of H2O2 , which enhances degradation of IkappaBalpha , enhances NF-kappaB activity [ 22b ] ; thus , macrophages have increased production of cyclooxygenase 2 ( Cox-2 ) , prostaglandin E2 ( PGE2 ) , and matrix metalloproteinase 1 ( MMP-1 ) [ 45 ] ."
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