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USP50 increases the amount of HMGB1. 2 / 2

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"Enhancing USP50 expression amplified bile acid-induced NLR family pyrin domain containing 3 (NLRP3) inflammasome activation and subsequent high-mobility group box protein 1 (HMGB1) release, while USP50 deficiency resulted in the reversed alteration."

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"Our study also found HMGB1 release can be enhanced by overexpression of USP50 in macrophages with bile acids stimulated."

38469295

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IndraLab

Statements

USP50 increases the amount of HMGB1. 2 / 2

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