IndraLab

Statements

OTUB1 activates BIRC2. 3 / 4
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reach
"Since OTUB1 also modulates the stability of cIAP1, it is a likely candidate that would explain the observed phenotype."
32764479
eidos
"Further , downregulation of ubiquitin thioesterase OTU domain ubiquitin aldehyde binding 1 ( OTUB1 ) enhances the degradation of cIAP1 and inhibits the TNF-related weak inducer of apoptosis ( TWEAK ) - induced MAPK and NF-kappaB pathway [ 33 ] ."
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reach
"OTUB1 modulates c-IAP1 stability to regulate signalling pathways."
23524849