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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

OTUB1 activates BIRC2. 3 / 4

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"Since OTUB1 also modulates the stability of cIAP1, it is a likely candidate that would explain the observed phenotype."

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"Further , downregulation of ubiquitin thioesterase OTU domain ubiquitin aldehyde binding 1 ( OTUB1 ) enhances the degradation of cIAP1 and inhibits the TNF-related weak inducer of apoptosis ( TWEAK ) - induced MAPK and NF-kappaB pathway [ 33 ] ."

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"OTUB1 modulates c-IAP1 stability to regulate signalling pathways."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...