IndraLab

Statements

ATXN3 decreases the amount of BCL2. 4 / 4
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"These findings underscore the efficacy of in vivo self-assembled mATXN3-siRNA in mitigating Purkinje cell apoptosis in YACMJD84.2 transgenic mice.Mutant ATXN3 has been found to upregulate Bax expression while downregulating Bcl-2 levels both in cellular and transgenic mouse models."
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"Moreover, polyQ expanded ataxin-3 was found to decrease mRNA and protein levels of the prosurvival Bcl-2 by affecting Bcl-2 mRNA stability [XREF_BIBR, XREF_BIBR]."
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"Expanding the polyglutamine tract of ataxin-3 protein, the target protein of SCA3, could decrease Bcl-2 expression and enhance cell death via mitochondria-dependent apoptosis [16] ."
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"The full-length expanded ATXN3 protein has been reported to accelerate mitochondrial-mediated cell death and decrease the expression of BCL2 proteins, which can aggravate the mitochondrial dysfunction in SCA3, as demonstrated in SK-N-SH-MJD78 cells [53]."
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