IndraLab

Statements

CACNA1C binds ANK3. 12 / 12
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"In summary, our study provides further evidence for the positive association of CACNA1C and ANK3 with SZ."
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"Since altered expression of these genes may affect ANK3 and CACNA1C native protein-protein (or genetic) interactions, we utilized STRING to visualize ANK3 and CACNA1C primary and secondary interacting partners."
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"While the role of oxytocin and dopamine is still being investigated in BD, our analysis suggests that ANK3 and CACNA1C may interact with proteins that play important roles in the etiology of BD, and alterations in ANK3 and CACNA1C protein expression may be detrimental to the endogenous function of these pathways."
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"In bipolar disorder, association with SNPs of ANK3 and CACNA1C was found by the combined analysis of three sample sets, which was consistent across three sample sets."
19507497
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"Based on a literature search, none of the predicted proteins that interact with ANK3 and CACNA1C are associated with BD or other neuropsychiatric disorders, although some are linked to epilepsy ( xref ; xref )."
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"As a result, this may lead to altered protein levels, thus affecting ANK3 and CACNA1C protein-protein interactions."
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"Excluding samples reported in that analysis xref , our bipolar sample was associated at CACNA1C (p=2.3×10 −4 ) and ITIH3/4 (p=0.0033) but not ANK3 ."
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"Interestingly, genetic association studies of schizophrenia (SCZ), which is another major psychotic disorder, have also revealed that the BD risk SNPs, such as CACNA1C and ANK3 , are associated with SCZ xref ."
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"We used STRING to determine the possible protein-protein (and genetic) interactions that may be adversely affected by changes in ANK3 and CACNA1C protein levels ( xref , xref )."
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"These findings that favor the hypothesis of a common set of pathological mechanisms accounting for BPD and MDD led us to investigate whether the recently identified genes, ANK3 and CACNA1C, associated[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Based on the hypothesis that both schizophrenia (SZ) and BD may share some common genetic risk factors, we investigated the association of CACNA1C and ANK3 with SZ using meta-analytic techniques, combining all published data up to April 2015."
26227746
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"Previous studies have shown rs9804190 in ANK3 and rs1006737 in CACNA1C are associated with altered expression of ANK3 and CACNA1C mRNA levels ( xref ; xref )."
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