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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

ATXN3 decreases the amount of MMP2. 3 / 4

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"On the one hand, ATXN3, HDAC3, and NCoR form a deacetylation complex to repress transcription of the MMP2 gene (Evert et al., 2006)."

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"Ataxin-3 is, for instance, able to repress matrix metalloproteinase-2 (MMP-2) transcription, and improved nuclear localisation of ataxin-3 through phosphorylation enhances this transcriptional repression [XREF_BIBR]."

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"Atxn3 UIMs were required to repress MMP2 transcription but Atxn3 catalytic DUB activity was not required."

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Statements

ATXN3 decreases the amount of MMP2. 3 / 4

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