IndraLab

Statements

ATXN3 decreases the amount of MMP2. 3 / 4
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"On the one hand, ATXN3, HDAC3, and NCoR form a deacetylation complex to repress transcription of the MMP2 gene (Evert et al., 2006)."
32581696
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"Ataxin-3 is, for instance, able to repress matrix metalloproteinase-2 (MMP-2) transcription, and improved nuclear localisation of ataxin-3 through phosphorylation enhances this transcriptional repression [XREF_BIBR]."
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"Atxn3 UIMs were required to repress MMP2 transcription but Atxn3 catalytic DUB activity was not required."
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