IndraLab

Statements

USP33 activates TGFB. 2 / 2
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"USP33, for example, promotes pancreatic cancer malignancy through the TGFBR2/TGF-β pathway , while inhibiting USP2 expression conversely activates TGF-β signaling and fuels glioblastoma development ."
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"Mechanistically, USP33 deubiquitinated and stabilized the TGFBR2 protein in PC cells and therefore enhanced the signaling of TGF-β pathway, USP33 removed the K63-linked ubiquitin conjugates from TGFBR2 and prevented its degradation by lysosome, meanwhile, USP33 promoted the recycling of TGFBR2 to cell membrane and eventually enhanced the signaling in TGF-β pathway."
37322017