IndraLab

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NEDD4L ubiquitinates KCNH2. 8 / 10
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"The hERG (human ether-a-go-go-related gene, Kv11.1, KCNH2) K channel, responsible for the IKr (rapid) current component in cardiac myocytes and mutated in type 2 long-QT syndrome, was reported to interact with NDFIP1 and NDFIP2 and was ubiquitinated by Nedd4-2 [55]."
39201565
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"Nedd4-2 ubiquitinates the epithelial sodium channel ENaC [XREF_BIBR], the chloride channel ClC-5, voltage gated potassium and the cardiac potassium channel hERG1 [XREF_BIBR]."
26608079
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"These two complementary methods enabled us to confirm that hERG1 was most likely directly ubiquitylated by Nedd4-2, since Nedd4-2 co-expression robustly increased the ubiquitylation of the channel."
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"As quantified in Fig. 5 B, only Nedd4-2 significantly increased the basal ubiquitylation of hERG1, while Nedd4-2-C801S and the other ubiquitin ligases had no effect."
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"Moreover, they also suggest that, at least in expression systems, the formation of a complex ubiquitin ligase-target protein is not inevitably followed by ubiquitylation of the protein.The present stu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Further experiments will be needed to confirm these results.In addition, hERG1 channels ubiquitylated by Nedd4-2 appear to be targeted to the proteasomal rather than to the lysosomal pathway, although[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Therefore, we proposed that increased Nedd4-2 activity in pCH enhanced ubiquitylation of Kv11.1 and accelerated its degradation, leading to I reduction and consequent arrhythmogenesis."
36059970
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"In conclusion, the results of the present work indicate that ubiquitylation of hERG1 by the ubiquitin ligase Nedd4-2 is a potentially constitutive physiological mechanism for the regulation of hERG1 c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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