IndraLab

Statements

XDH binds USP15. 7 / 7
3 | 1 3
sparser
"Mechanistically, XOR physically interacts with USP15, thereby promoting deubiquitination of Kelch Like ECH Associated Protein 1 (KEAP1) to stabilize its expression, which leads to degradation of Nrf2 via ubiquitination and subsequently reactive oxygen species (ROS) accumulation in liver CSCs."
31578733
sparser
"In addition, xanthine oxidoreductase (XOR) can interact with USP15 to enhance the stability of Kelch-like ECH-associated protein 1 (KEAP1), which ultimately promotes the accumulation of reactive oxygen species (ROS) and liver cancer stem cells (CSCs) ( xref )."
35875077
reach
"Mechanistically, XOR physically interacts with USP15, thereby promoting deubiquitination of Kelch Like ECH Associated Protein 1 (KEAP1) to stabilize its expression, which leads to degradation of Nrf2 via ubiquitination and subsequently reactive oxygen species (ROS) accumulation in liver CSCs."
31578733
biogrid
No evidence text available
31578733
biogrid
No evidence text available
31578733
biogrid
No evidence text available
31578733
sparser
"USP15 physically interacts with XOR and stabilizes Kelch-like ECH, which is attributed to ROS accumulation in hepatocellular carcinoma [ xref ]."
36163170