IndraLab

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BAP1 inhibits Mice. 4 / 4
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"For example, differentiation to mature neurons and glia could require antagonism of PRC-mediated transcriptional repression.We were thus intrigued by our serendipitous discovery that Bap1 deletion in ENS lineages caused profound bowel dysfunction and early death in mice, mimicking human nCIPO or HSCR physiology."
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"Thus, it is not surprising that human BAP1 mutations predispose to cancer (18) and global Bap1 knockout causes early embryonic lethality in mice (38)."
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"We discovered that fetal loss of the epigenetic regulator Bap1 in the ENS lineage caused severe postnatal bowel dysfunction and early death in Tyrosinase-Cre Bap1 fl/fl mice."
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"We found that loss of BAP1 leads to the development of chronic pancreatitis in mice and is associated with poor prognosis in PDA patients."
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