IndraLab

Statements

LMP1 activates UCHL1. 5 / 5
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"In addition, we demonstrate that EBV LMP1 can also activate the uch-l1 promoter and increase levels of UCH-L1."
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"The latent KSHV gene LANA has also been shown to induce UCH-L1, and co-infection has shown that LANA and LMP1 synergize to activate UCH-L1, promoting a tumorigenic phenotype with an increase in proliferation, adhesion, cell migration and apoptosis inhibition [102]."
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"Finally, the mechanism by which LANA and LMP1 induce the uch-l1 promoter was explored."
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"The finding that KSHV LANA can itself induce the expression of EBV LMP1 suggests there is a second mechanism through which UCH-L1 levels are augmented in co-infected cells : LANA activates the expression of LMP1, which in turn activates the uch-l1 promoter, resulting in greater levels of UCH-L1."
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"Therefore, SP1, STAT3, and c-JUN are likely candidates to contribute to LANA- and LMP1 induced activation of the uch-l1 promoter and will be the subject of future studies."
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