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Phenethyl caffeate inhibits NLRP3. 23 / 23
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"Moreover, CAPE significantly inhibited the formation of ASC dimers and reduced the abundance of NLRP3 inflammasome complexes in a dose dependent manner (XREF_FIG)."
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"We examined whether CAPE could suppress uric acid crystals induced NLRP3 inflammasome activation in gout."
27934918
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"This study suggests another mechanism by which CAPE suppresses activation of the NLRP3 inflammasome."
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"We investigated the mechanism by which CAPE suppresses NLRP3 inflammasome activation."
27934918
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"These results show that CAPE suppresses NLRP3 inflammasome activation mediated by other activators, such as ATP and nigericin in macrophages."
27934918
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"In conclusion, CAC can be prevented by CAPE induced NLRP3 inflammasome inhibition, highlighting CAPE as a potential candidate for reducing the risk of CAC in patients with inflammatory bowel disease."
32435622
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"CAPE suppresses uric acid crystal induced NLRP3 inflammasome activation in bone marrow derived primary macrophages."
27934918
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"CAPE was also shown to suppress NLRP3 inflammasome activity in human aortic valve interstitial cells (AVICs) cultured in osteogenic induction medium [XREF_BIBR]."
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"To determine whether CAPE inhibits NLRP3 inflammasome in vivo, we assessed NLRP3 expression in the AOM and DSS mouse model by immunohistochemistry and western blotting."
32435622
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"In primary mouse macrophages, caffeic acid phenethyl ester (CAPE) blocked caspase-1 activation and IL-1beta production induced by MSU crystals, showing that CAPE suppresses NLRP3 inflammasome activation."
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"We found that CAPE decreased NLRP3 inflammasome activation in BMDMs and THP-1 cells and protected mice from colorectal cancer induced by AOM and DSS."
32435622
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"CAPE inhibited NLRP3 inflammasome activation by blocking caspase-1 activation and IL-1beta production induced by MSU crystals."
33534121
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"Co-immunoprecipitation study showed that CAPE prevented MSU induced association of NLRP3 and ASC in BMDMs (XREF_FIG)."
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"CAPE Decreases NLRP3 Inflammasome Activation in BMDMs and THP-1 Cells."
32435622
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"In conclusion, CAC can be prevented by CAPE-induced NLRP3 inflammasome inhibition, highlighting CAPE as a potential candidate for reducing the risk of CAC in patients with inflammatory bowel disease."
32435622
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"Therefore, we examined whether CAPE could inhibit NLRP3 inflammasome activation mediated by other activators, such as ATP and nigericin."
27934918
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"We first investigated whether CAPE inhibits the activation of NLRP3 inflammasome induced by ATP and LPS in macrophages in vitro."
32435622
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"These results suggest that CAPE suppresses the activation of the NLRP3 inflammasome by directly binding ASC, blocking the association of NLRP3 and ASC."
27934918
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"Although some elegant studies have shown that oridonin or CAPE inhibits activation of the NLRP3 inflammasome through unique mechanisms or by targeting multiple targets, more investigation is warranted to elucidate the detailed molecular mechanisms that enable each natural compound to inhibit the NLRP3 inflammasome."
33535473
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"Overall, the results indicate that activated NLRP3 in AOM and DSS mouse model is suppressed by CAPE."
32435622
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"We first investigated whether CAPE could block the activation of NLRP3 inflammasome induced by uric acid crystals."
27934918
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"The results show that CAPE suppressed the activation of NLRP3 inflammasome in murine macrophages and human monocytic cells."
27934918
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"Instead , during NLRP3 inflammasome activation , CAPE suppressed deubiquitination of the NLRP3 protein , which is a prerequisite for the assembly of the NLRP3 inflammasome complex [ 5 ] ."
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