IndraLab

Statements


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sparser
"To investigate if Snail1 can indeed bind and regulate the USP4 promoter, luciferase reporter constructs were generated in which luciferase expression was controlled by the wild type USP4 promoter or promoters with the E-box sequence mutations shown in xref and co-transfected with Snail1 into HEK293 cells."

No evidence text available

sparser
"LOXL3 interacts with the snail family transcriptional repressor 1 (Snail1), and Snail1 binds to the promoter of USP4, while USP4 deubiquitinates and stabilizes the expression of Snail1, thus forming a regulatory loop xref ."

reach
"Mechanistically, LOXL3 interacted with snail family transcriptional repressor 1 (Snail1) through STRING database and RIP assay, and Snail1 bound to ubiquitin-specific peptidase 4 (USP4) promoter by JASPAR database, luciferase reporter gene and Co-IP assays."