IndraLab

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KCNQ1 activates pyraclofos. 7 / 7
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"On one hand, voltage dependent KCNQ1 (KvLQT1) channels can coassemble with some members of the MiRP (KCNE) family of single transmembrane spanning proteins to produce a voltage independent K + current."
16446506
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"In the heart, coassembly of KCNQ1 with KCNE1 elicits voltage- and time dependent K + currents (I KS) with very slow activation kinetics, a positive shift in the voltage dependence of activation, and an increase in unitary channel conductance, in comparison to homomeric KCNQ1 channels."
15226366
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"In contrast, co-assembly of KCNQ1 and KCNE3 produces a current with nearly instantaneous activation, some time dependent activation at very positive potentials, and a linear current voltage relationsh[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11448722
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"In mouse pancreatic acini KCNQ1 probably co-assembled with KCNE1 leads to a voltage dependent K (+) current that might be of importance for electrolyte and enzyme secretion."
11889581
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"ML277 is a particularly interesting and potent KCNQ1 activator, which increases peak currents dramatically in mammalian cells by enhancing voltage-dependent activation and eliminating inactivation ."
35768468
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"This different expression pattern of KCNQ1 isoforms in NCI-H295 cell line with the lack of the mRNA for the dominant negative KCNQ1 isoform 2 supports the involvement of voltage gated K+ channel in cell proliferation."
16610241
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"It later turned out that the exogenous KCNE1 gene could upregulate the endogenous (Xenopus) KCNQ1 channels.KCNQ1 channel can produce voltage‐dependent outward K current as a homotetramer."
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