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Delta12-PGJ2 inhibits UCHL3. 3 / 3
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"As shown in Fig. 5, Delta12-PGJ2 inhibited the activities of UCH-L1 (K i = 3.49 muM +/- 0.42, Fig. 5A) and UCH-L3 (K i = 8.1 muM +/- 0.8, Fig. 5B), indicating that this PGJ2 metabolite is an efficient[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Delta12-PGJ2 and 15Delta-PGJ2 are potent cyclopentone PGs and have been reported to inhibit UCH-L3 and UCH-L1 respectively [282,283]."
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"Since Delta12-PGJ2 inhibited UCH-L1 and UCH-L3 activities, we postulated that this cyclopentenone prostaglandin would affect the endogenous levels of ubiquitinated proteins."
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