IndraLab

Statements

USP18 activates CGAS. 3 / 3
| 3
reach
"Taken together, USP18 may reduce cGAS degradation by deubiquitinating it thereby maintaining cGAS-STING pathway activation.Finally, we determined that cGAS-STING pathway is involved in USP18-mediated [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37422930
reach
"According to several studies, IAV upregulates USP18 expression, which enhances cGAS stability, leading to prolonged activation of the cGAS/STING pathway, thereby triggering apoptosis and promoting viral replication ."
39550441
reach
"Compared with si-NC group, cGAS was degraded more quickly in si-USP18 group ( Fig. 4 B), which indicated that inhibition of USP18 impaired the stability of cGAS."
37422930