IndraLab

Statements

USP1 inhibits BRCA1. 3 / 3
| 3
reach
"Because TS requires BRCA1 (50), USP1 inhibition may lead to inconclusive repair in BRCA1 mutant cells."
36228090
reach
"However, although USP1 inactivation using the selective inhibitor ML323 ( Liang et al., 2014 ) produces a synthetic lethal phenotype in BRCA1-deficient cells, experimental evidence supported that a la[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33984284
reach
"Given that USP1 suppresses BRCA1, we expect that compromising APC function would also lead to an apparent suppression on BRCA1 focus formation."
28604711