IndraLab

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OTUD6A deubiquitinates DNM1L. 3 / 4
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"For instance, OTUD6A deubiquitinates and stabilizes Drp1 to regulate mitochondrial morphology in colon cancer, and it plays a critical role in promoting tumor cell resistance to chemoradiotherapy by deubiquitinating and stabilizing TopBP1 [35,36]."
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"OTUD6A interacts with and deubiquitinates Drp1 to enhance mitochondrial fission [49]."
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"Furthermore, overexpression of deubiquitinating enzyme 6A (OTUD6A) promotes deubiquitination of Drp1, which increases proliferation and cloning of CRC cells."
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