IndraLab

Statements

Modified USP10 increases the amount of TP53. 3 / 3
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"Overexpression of USP10 significantly increased the levels of endogenous p53, with no effect on p53 mRNA levels (XREF_FIG)."
20096447
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"Consistent with this study, we show that increased USP10 expression in mutant p53 background increases p53 levels and promotes cancer cell proliferation, while downregulation of USP10 inhibits cancer cell growth."
20096447
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"Furthermore, overexpression of USP10 in 786-O cells increases levels of mutp53, leading to enhanced colony formation and proliferation, which is nullified by depletion of mutp53."
30577483