IndraLab

Statements

USP37 is phosphorylated on S628. 7 / 7
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sparser
"In G1/S, Ser628 of USP37 is phosphorylated by either CDK2/cyclin E or CDK2/cyclin A, and this triggers USP37 full DUB activity."
32512887
sparser
"In vivo deubiquitination assays and in vitro kinase assays indicated that phosphorylation of USP37 at Ser628 had no regulatory effect on targeting SND1 for deubiquitination ( xref ), and CDK2-mediated phosphorylation of USP37 at Ser628 did not mediate the phosphorylation of USP37 at Thr631 ( xref )."
40486858
sparser
"Ser 628 of USP37 was phosphorylated in G1/S, but not mitosis ( Figure 7 E)."
21596315
sparser
"Hence, we sought to determine whether phosphorylation of USP37 at Ser628 enhances targeting for deubiquitination of SND1 and whether CDK2 could also mediate phosphorylation of USP37 at Thr631."
40486858
rlimsp
"The USP37 protein becomes fully functional upon its Cyclin A/CDK2-mediated phosphorylation at Ser-628 residue [6] and remains active throughout the S phase upto G2/M boundary."
25347529
sparser
"Dixit et al. xref reported that CDK2 mediates the phosphorylation of USP37 at Ser628."
40486858
rlimsp
"A recent study implicates the phosphorylation of Ser-628 of USP37 to protect it from CDH1 mediated ubiquitination [6]."
25347529