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"Furthermore, it has been reported most recently that the genetic inhibition of JAB1 using knock-down gene expression abrogated the binding of the inhibitory Ikappa-Balpha subunit to NF-kappaB and enhanced TNF-alpha production in EC, while JAB1 overexpression had the opposite effect, suggesting a crucial role of JAB1 after TNF-alpha stimulation [XREF_BIBR]."