IndraLab

Statements

SCN5A binds NEDD4. 9 / 9
4 | 2 3
sparser
"For example, the E3 ubiquitin ligase WWP2 selectively targets PARP1 for ubiquitination and degradation to regulate isoproterenol-induced cardiac remodeling (Zhang et al. xref ), FAT10 prevents ischemia-induced ventricular arrhythmias by reducing the formation of the Nedd4-2/Nav1.5 complex (Liu et al. xref ), and the muscle-specific ubiquitin ligase atrogin-1 targets signaling proteins involved in cardiac hypertrophy for degradation (Li et al. xref )."
37953295
biogrid
No evidence text available
15217910
biogrid
No evidence text available
15548568
biogrid
No evidence text available
15217910
sparser
"Human leukocyte antigen F-associated transcript 10 (FAT10) of the small ubiquitin-like protein family binds to lysine residues in the C-terminal fragment of Nav1.5 and diminishes the binding of Nav1.5 to Nedd4-2, blocking its degradation by the UPS after an MI and suppresses ischemia-induced VAs [ xref ]."
40630435
sparser
"FAT10 antagonizes Nav1.5 ubiquitination through the C-terminal domain by decreasing the formation of the Nedd4-2–Nav1.5 complex."
33414395
reach
"The increased O-GlcNAc-modified Nav1.5 was correlated with the decreased interaction between Nav1.5 and Nedd4–2 or SAP-97 in the cardiac tissue of STZ rats in the co-immunoprecipitation assays, as dis[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29530619
biogrid
No evidence text available
31614475
reach
"Ankyrins, fibroblast growth factor homologous factor 1B, calmodulin, caveolin-3, Nedd4-like ubiquitin-protein ligases, dystrophin, syntrophin, glycerol 3-phosphate dehydrogenase 1-like protein (GPD1L), and RAN guanine nucleotide release factor (MOG1) can directly bind to Nav1.5 and regulate Na channel transport, expression, and gating [75,76,77]."
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