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Statements

SCN5A binds NEDD4. 4 / 8
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"For example, the E3 ubiquitin ligase WWP2 selectively targets PARP1 for ubiquitination and degradation to regulate isoproterenol-induced cardiac remodeling (Zhang et al. xref ), FAT10 prevents ischemia-induced ventricular arrhythmias by reducing the formation of the Nedd4-2/Nav1.5 complex (Liu et al. xref ), and the muscle-specific ubiquitin ligase atrogin-1 targets signaling proteins involved in cardiac hypertrophy for degradation (Li et al. xref )."
37953295
reach
"The increased O-GlcNAc-modified Nav1.5 was correlated with the decreased interaction between Nav1.5 and Nedd4–2 or SAP-97 in the cardiac tissue of STZ rats in the co-immunoprecipitation assays, as dis[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29530619
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"Ankyrins, fibroblast growth factor homologous factor 1B, calmodulin, caveolin-3, Nedd4-like ubiquitin-protein ligases, dystrophin, syntrophin, glycerol 3-phosphate dehydrogenase 1-like protein (GPD1L), and RAN guanine nucleotide release factor (MOG1) can directly bind to Nav1.5 and regulate Na channel transport, expression, and gating [75,76,77]."
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"FAT10 antagonizes Nav1.5 ubiquitination through the C-terminal domain by decreasing the formation of the Nedd4-2–Nav1.5 complex."
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