IndraLab

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TRIM21 binds COPS6. 14 / 14
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"Notably, studies have unveiled intriguing interactions, for instance, PKMYT1's physical interaction with β-catenin, which stabilizes β-catenin protein and activates Wnt signaling, bolstering non-small cell lung cancer CSC self-renewal. xref Additionally, the CSN6-TRIM21 axis has surfaced, spotlighting its role in driving cancer stemness during tumorigenesis."
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"Besides, the signaling axis of CSN6-TRIM21 was reported to promote tumor stemness during tumorigenesis ( xref )."
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"To verify Cullin 's involvement, we first showed that TRIM21 interacted with CUL1 and CSN6 by Co-IP."
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"TRIM21 binding with CSN6 is enhanced by the presence of CUL1 (Fig.  xref )."
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"TRIM21 binding with CSN6 is enhanced by the presence of CUL1."
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"In addition, TRIM21’s function is associated with autoimmune diseases, such as systemic lupus erythematosus (SLE) and Sjögren’s syndrome. xref , xref Notably, patients with SLE or Sjögren’s syndrome have an increased risk for developing certain cancers, including non-Hodgkin’s lymphoma. xref In addition, TRIM21 interacts with endoglin, xref which is a prognostic marker in CRC xref and also act as a CSC marker in renal cell carcinoma. xref Future studies will need to address how the CSN6–TRIM21 axis may impact these signalling pathways to promote tumorigenesis."
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"This finding aligns with a previous report that the CSN6-TRIM21 axis drives colorectal cancer stemness [ xref ]."
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"In conclusion, we validate a pathway for cancer stemness regulation involving ALDH1A1 levels through the CSN6–TRIM21 axis, which may be utilised as CRC molecular markers and be targeted for therapeutic intervention in cancers."
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"Then we confirmed that CSN6 could interact with TRIM21 in HCT116 cells by Co-IP (Fig.  xref )."
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"The MPN domain (41–174 aa) is located in N-terminal and is indispensable in CSN6’s impact on Cullin-1 neddylation. xref Then we further identified the domain of CSN6 responsible for its interaction with TRIM21 and found that the MPN domain of CSN6 bound to TRIM21 (Fig.  xref )."
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"Collectively, the above results consistently suggest that CSN6 interacts with TRIM21, which in turn impacts Aldh1a1 mRNA expression."
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"Then we confirmed that CSN6 could interact with TRIM21 in HCT116 cells by Co-IP."
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"Collectively, the above results consistently suggest that CSN6 interacts with TRIM21, which in turn impacts Aldh1a1 mRNA expression."
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"Our results provide insight into the consequence of CSN6–TRIM21 signalling on OCT1/ALDH1A1 expression during carcinogenesis and cancer progression."
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