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BAP1 inhibits Neoplasm Invasiveness. 21 / 21
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"All of these results further confirmed that BAP1 suppressed ICC cell proliferation , cell cycle progression , and invasion via inhibiting ERK1 / 2 and JNK / c-Jun signaling pathways ."
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"Transwell migration and invasion assays revealed that BAP1 overexpression inhibited MSC migration and invasion (Fig. 2E, F)."
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"Additionally, BAP1 regulates EMT during trophoblast differentiation and invasion, while decreased BAP1 expression triggers EMT and enhances migration and invasion (27)."
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"Because BAP1 is frequently mutated in UM cells and is closely associated with metastasis ( Harbour et al., 2013; Maerker et al., 2014 ), knockdown of BAP1 was expected to promote cell invasiveness."
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"Moreover, both scratching assay and Matrigel invasion assay indicated that overexpression of BAP1 in HCCC9810 cells significantly reduced cell migratory and invasion capacities, while the motility and invasion potential of RBE-shBAP1 cells were evidently enhanced compared to RBE-Mock cells (Fig. 2d, e)."
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"Wild-type BAP1 but not mutant BAP1 significantly inhibited HCC cell proliferation, invasion, epithelial-mesenchymal transition (EMT) in vitro, and tumor progression and metastasis in vivo."
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"Importantly, loss of BAP1 decreased the formation of stress fibers and membrane protrusions and induced migration and invasion defects."
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"In functional assays, BAP1 was found to inhibit the migration and invasion of LAC cells, and promoted their apoptosis and necrosis."
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"Importantly, loss of BAP1 decreased the formation of stress fibers and membrane protrusions and induced migration and invasion defects."
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"Likewise, cell proliferation, G1-phase to S-phase cell cycle progression, and invasion of HCCC9810 cells were significantly inhibited by transfection of wild-type BAP1 but not inactive mutant BAP1C91A (Fig. 4c, d)."
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"These results indicated that BAP1 suppressed ICC cell proliferation, cell cycle progression, and invasion via inhibiting ERK1/2 and JNK/c-Jun signaling pathways.To further validate these findings, we used inhibitors of the ERK1/2 pathway (U0126) and JNK/c-Jun pathway (SP600125) in RBE-shBAP1 cells."
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"All of these results further confirmed that BAP1 suppressed ICC cell proliferation, cell cycle progression, and invasion via inhibiting ERK1/2 and JNK/c-Jun signaling pathways."
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"Finally, to elucidate the mechanism by which BAP1 suppresses invasion and metastasis in LAC cells, we analyzed the expression levels of metastasis related proteins in transfected H1299 cells and H1650 cells using IB, respectively."
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"Functionally, BAP1 promotes apoptosis and necrosis, and down-regulates the migration and invasion abilities of LAC cells."
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"Taken together , these data revealed that downregulation of BAP1 promotes proliferation , G1 to S cell cycle progression , and invasion of ICC in vitro ."
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"Conversely, BAP1 overexpression reduced the migration and invasion capabilities of MSCs."
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"These results indicated that BAP1 suppressed ICC cell proliferation , cell cycle progression , and invasion via inhibiting ERK1 / 2 and JNK / c-Jun signaling pathways ."
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"BAP1 inhibits migration and invasion abilities of cells in vitro."
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"Recent insights from Mei et al. confirmed that BAP1 silencing in trophoblast cells promotes cell proliferation, invasion, and migration, accompanied by molecular changes indicative of EMT ."
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"Here, we demonstrate that BAP1 deletion leads to the overactivation of the nuclear factor-kappaB (NF-kappaB) signaling in PDAC, thereby promoting the proliferation, migration, and invasion of PDAC models both in vivo and in vitro."
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"BAP1 loss promotes the proliferation, migration and invasion of PDAC cells."
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