IndraLab

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BAP1 inhibits Neoplasm Invasiveness. 15 / 15
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"Early changes resulting in gain of chromosome 8q may activate macrophage infiltration, while sequential loss of BAP1 expression seems to drive T cell infiltration in UM."
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"All of these results further confirmed that BAP1 suppressed ICC cell proliferation , cell cycle progression , and invasion via inhibiting ERK1 / 2 and JNK / c-Jun signaling pathways ."
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"Importantly, loss of BAP1 decreased the formation of stress fibers and membrane protrusions and induced migration and invasion defects."
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"Likewise, cell proliferation, G1-phase to S-phase cell cycle progression, and invasion of HCCC9810 cells were significantly inhibited by transfection of wild-type BAP1 but not inactive mutant BAP1C91A (Fig. 4c, d)."
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"Functionally, BAP1 promotes apoptosis and necrosis, and down-regulates the migration and invasion abilities of LAC cells."
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"All of these results further confirmed that BAP1 suppressed ICC cell proliferation, cell cycle progression, and invasion via inhibiting ERK1/2 and JNK/c-Jun signaling pathways."
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"In functional assays, BAP1 was found to inhibit the migration and invasion of LAC cells, and promoted their apoptosis and necrosis."
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"Moreover, both scratching assay and Matrigel invasion assay indicated that overexpression of BAP1 in HCCC9810 cells significantly reduced cell migratory and invasion capacities, while the motility and invasion potential of RBE-shBAP1 cells were evidently enhanced compared to RBE-Mock cells (Fig. 2d, e)."
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"These results indicated that BAP1 suppressed ICC cell proliferation, cell cycle progression, and invasion via inhibiting ERK1/2 and JNK/c-Jun signaling pathways.To further validate these findings, we used inhibitors of the ERK1/2 pathway (U0126) and JNK/c-Jun pathway (SP600125) in RBE-shBAP1 cells."
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"Wild-type BAP1 but not mutant BAP1 significantly inhibited HCC cell proliferation, invasion, epithelial-mesenchymal transition (EMT) in vitro, and tumor progression and metastasis in vivo."
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"BAP1 inhibits migration and invasion abilities of cells in vitro."
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"These results indicated that BAP1 suppressed ICC cell proliferation , cell cycle progression , and invasion via inhibiting ERK1 / 2 and JNK / c-Jun signaling pathways ."
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"Finally, to elucidate the mechanism by which BAP1 suppresses invasion and metastasis in LAC cells, we analyzed the expression levels of metastasis related proteins in transfected H1299 cells and H1650 cells using IB, respectively."
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"Importantly, loss of BAP1 decreased the formation of stress fibers and membrane protrusions and induced migration and invasion defects."
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"Taken together , these data revealed that downregulation of BAP1 promotes proliferation , G1 to S cell cycle progression , and invasion of ICC in vitro ."
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