IndraLab

Statements

KCNQ1 inhibits cell population proliferation. 7 / 7
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"This suggests KCNQ1 expression can suppress OAC proliferation, and KCNQ3 expression can promote it in some contexts, confirming that activity of these channels is sufficient to induce changes in cellular proliferation, prompting us to study an in vivo model, which may be more functionally relevant.To bolster our findings and explore their generality, we looked to a murine Prom1 ; Kras ; Trp53 model of GOA (25)."
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"miR-483–5p promoted EC cell proliferation, migration and invasion by silencing KCNQ1."
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"Furthermore, downregulation of the KCNQ1 subunit KCNE2 in gastric cancer inhibits cell proliferation and tumor occurrence in the stomach (Yanglin et al., 2007)."
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"Zhang et al. showed that ANPs played a pleiotropic role in gastric cancer cell proliferation, and the physiological concentration of ANPs upregulated the expression of the potassium-voltage-gated channel and KQT-like subfamily member 1 (KCNQ1) to promote AGS cell proliferation, while the pharmacological concentration of ANP significantly downregulated KCNQ1 expression to inhibit AGS proliferation [114]."
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"In esophageal squamous cell carcinoma (ESCC), miR-483e5p overexpression silences KCNQ1 promoting cell proliferation, migration, and invasion [78]."
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"Furthermore, the KCNQ1 subunit KCNE2, which is downregulated in GC, was demonstrated to suppress cell proliferation and tumorigenesis of the stomach [116]."
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"In summary, our data reveal that KvLQT1 channel blockade efficiently reduces A549 and H460 cell proliferation and migration."
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