IndraLab

Statements

USP46 binds GST. 3 / 3
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sparser
"In addition, a significant decrease of polyubiquitinated NRAS Q61R was observed when incubated with purified GST-USP46 WT rather than the C44S mutant in vitro (Fig. xref )."
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"As shown in Fig. xref , purified GST-USP46 interacted with the NRAS Q61R and NRAS Q61K mutant more strongly than NRAS WT and Q61L. We also modeled the structure of ubiquitinated NRAS in complex with USP46 using protein-protein docking (Schrödinger, LLC, New York, NY, 2023) based on the USP46-UB complex structure (PDB ID: 5CVM) and NRAS Q61K (PDB ID: 8VM2)."
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"Additionally, purified GST-USP46 interacted with the NRAS Q61R mutant much more strongly than KRAS WT, HRAS WT and their mutants (Supplementary Fig.  xref )."
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