IndraLab

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Hedgehog activates USP8. 2 / 5

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"CFP-Smo was transfected into S2 cells that were treated with GFP dsRNA (control), USP8 dsRNA, or Shi dsRNA and then treated with Hh conditioned medium or control medium."

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"Mechanistically, we show that Hh promotes the interaction of USP8 with Smo aa625-753, which covers the three PKA and CK1 phosphorylation clusters."

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IndraLab

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Hedgehog activates USP8. 2 / 5

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