IndraLab

Statements

TP53 decreases the amount of KCNH1. 7 / 7
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"Evidently, p53 negatively regulates expression of h-eag1."
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"This is consistent with a recent report that Eag expression is negatively regulated by p53 through p53-miR34-E2F1 pathway in human neuroblastoma cells SHSY5Y."
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"Activation of p53, which results in cell cycle arrest or apoptosis, reduced the expression of Eag1 channel."
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"Therefore, p53 negatively regulates h-eag1 expression by a negative feed-forward mechanism through the p53-miR-34-E2F1 pathway."
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"Therefore, p53 negatively regulates h-eag1 expression by a negative feed-forward mechanism through the p53-miR-34-E2F1 pathway and inactivation of p53 activity as it is the case in many cancers can thus cause oncogenic overexpression of h-eag1 by relieving the negative feed-forward regulation."
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"Moreover, the activation of p53 by nutlin-3 induced cell growth arrest in MG-63 cells and reduced Eag protein level, while the inactivation of p53 by pifithrin-alpha (PFT-alpha) promoted MG-63 cell growth and increased Eag protein expression."
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"A recent report showed that Eag1 expression was negatively regulated by p53 through p53-miR34-E2F1 pathway in human neuroblastoma cells XREF_BIBR."
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