IndraLab

Statements

USP8 activates Neoplasm Metastasis. 8 / 8
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"Usp8 promotes tumor cell migration through activating the JNK pathway ."
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"As USP8 silencing significantly inhibited the PCa cell growth, proliferation, and metastasis and induced apoptosis and suppressed NF-kB signal activation by decreasing EGFR and PI3K, the USP8-specific inhibitor might be a novel therapeutic target to suppress PCa cell growth, proliferation, and metastasis."
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"Knockdown of USP8 inhibits prostate cancer cell growth , proliferation , and metastasis and promotes docetaxel 's activity by suppressing the NF-kB signaling pathway Ubiquitin-specific protease 8 ( USP8 ) has been recently reported to be involved in tumorigenesis ."
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"USP8 regulates NF-kappaB activation through EGFR and PI3K stabilization to promote PCa cell proliferation and survival In multiple studies ( 29-32 ) , the EGFR is a substrate of USP8 deubiquitination , while USP8 has been shown to enhance gastric cancer cell proliferation and metastasis via the PI3K / AKT signaling pathway ( 30 ) ."
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"Knockdown of USP8 inhibits prostate cancer cell growth, proliferation, and metastasis and promotes docetaxel's activity by suppressing the NF-kB signaling pathway."
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"USP8 promotes TGF-β/SMAD-induced epithelial-mesenchymal transition (EMT), invasion, and metastasis in tumor cells."
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"In multiple studies (29–32), the EGFR is a substrate of USP8 deubiquitination, while USP8 has been shown to enhance gastric cancer cell proliferation and metastasis via the PI3K/AKT signaling pathway (30)."
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"Here , we find that the ubiquitin-specific protease 8 ( Usp8 ) promotes tumor cell migration through activating the c-Jun N-terminal kinase ( JNK ) pathway ."
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