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1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile inhibits KCNH2. 4 / 4
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"No statistical difference between citalopram blockade of HERG (tail current maximum at -40 mV) in the two heterologous systems in the two sets of recording conditions was observed at the two concentra[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11852052
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"Both escitalopram and citalopram produced a reduction of hERG channel protein trafficking to the plasma membrane but did not affect the short-term internalization of the hERG channel."
24045971
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"Fluoxetine and its metabolite, norfluoxetine, citalopram and escitalopram prolong the QT interval by directly inhibiting the hERG potassium channels and by disrupting channel protein trafficking reducing the number of channels on the cell membrane [XREF_BIBR]."
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"Using whole-cell patch clamp recording of heterologous HERG mediated currents in transfected mammalian cells, we observed that the selective serotonin re-uptake inhibitor citalopram blocks HERG with an IC (50) of 3.97 microM."
11852052