IndraLab

Statements

USP12 translocates to the nucleus. 5 / 5
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"USP12 translocates into the nucleus in IFN signaling, which critically regulates nuclear p-STAT1 levels and IFN antiviral activity by inhibiting CBP’s acetyltransferase activity."
31899788
reach
"Moreover, USP12, which is a cell-intrinsic inhibitor of the acetyltransferase, CBP, translocates into the nucleus and regulates the nuclear-p-STAT1-mediated antiviral response independent of its deubiquitinase activity [21]."
37410794
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"Further investigations are required to elucidate how USP12 is translocated to the nucleus."
38455765
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"Given that we have demonstrated that USP12 translocates into the nucleus in IFN signaling, we next sought to determine whether USP12 regulates p-STAT1 levels through CBP."
31899788
reach
"Lehoux et al., found that USP12 and USP46 fused to red fluorescent protein were predominantly cytoplasmic in C33A cervical carcinoma cells, but were recruited to the nucleus via an interaction with the HPV E1 helicase [XREF_BIBR]."
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