IndraLab

Statements

USP10 increases the amount of TP53. 5 / 6
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"Reconstitution of USP10 in CAKI-1 and CAKI-2 (WT p53 cell lines) restored p53 expression and increased p21 and BAX expression (XREF_SUPPLEMENTARY)."
20096447
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"In accordance with published work, we detected that knockdown of USP10 is sufficient to reduce p53 protein levels."
30067985
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"These results suggest that USP10 can upregulate p53 levels, most likely by deubiquitinating and consequently stabilizing p53."
20096447
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"In accordance with published work, we detected that knockdown of USP10 is sufficient to reduce p53 protein levels (Yuan et al., 2010)."
30067985
reach
"Both, the DUB HAUSP (herpesvirus associated ubiquitin specific protease) and USP10 (ubiquitin specific protease 10), targeting poly-ubiquitinated p53, have been shown to restore p53 levels even when Hdm2 is overexpressed."
24756373