IndraLab

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USP10 increases the amount of TP53. 8 / 10
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"These results suggest that USP10 can upregulate p53 levels, most likely by deubiquitinating and consequently stabilizing p53."
20096447
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"Reconstitution of USP10 in CAKI-1 and CAKI-2 (WT p53 cell lines) restored p53 expression and increased p21 and BAX expression (XREF_SUPPLEMENTARY)."
20096447
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"Both, the DUB HAUSP (herpesvirus associated ubiquitin specific protease) and USP10 (ubiquitin specific protease 10), targeting poly-ubiquitinated p53, have been shown to restore p53 levels even when Hdm2 is overexpressed."
24756373
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"Increased USP10 expression in mutant p53 background increases p53 levels and promotes cancer cell proliferation, while downregulation of USP10 inhibits cancer cell growth."
25444757
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"USP10 counteracts the degradation of p53 by MDM2, thereby maintaining the dynamic equilibrium of p53.A related study showed that reconstituting USP10 in RCC cells with downregulated USP10 restores p53 expression and inhibits colony formation as well as cell proliferation in RCC cells."
39748950
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"Notably, we found that USP10 bound with HSPA12A in CF, and inhibition of USP10 not only reversed the HSPA12A-induced upregulation of p53 protein levels, but also reversed the HSPA12A-induced inhibition of glycolysis and activation of CF."
38219869
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"In accordance with published work, we detected that knockdown of USP10 is sufficient to reduce p53 protein levels."
30067985
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"Furthermore, USP10 restoration significantly increased p53 and p21 expression, while miR-1244 and USP10 affected CDK2 and CCNE2 expressions (Fig. 6E and S8A)."
38515149