IndraLab

Statements

EZH2 binds OTUD6A. 3 / 3
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"Additionally, we uncovered the mechanism by which OTUD6A activates EZH2: 1) OTUD6A directly interacts with EZH2; 2) OTUD6A cleaves K48-linked polyubiquitin chains on EZH2 at lysine 569, thereby preventing its proteasomal degradation and enhancing the stability and levels of EZH2; 3) OTUD6A elevation of EZH2 and H3K27me3 protein levels in primary hepatocytes treated with APAP contributed to decreased ER stress and reduced hepatocyte death."
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"In conclusion, our data suggest that targeting the OTUD6A–EZH2 axis may represent a viable therapeutic approach for DILI."
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"We employed the EZH2 inhibitor, GSK126, to validate the role of the OTUD6A-EZH2 axis ( xref C)."
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