IndraLab

"100 Loss of USP19 increases transcription of myofibrillar proteins in L6 muscle cells and decreases muscle wasting in response to denervation in mice Priyanka Sundaram 1, Zhiyu Pang 2, Miao Miao 1, Nathalie Bedard 2, Tamara Moore 2, Patricia L. Hallauer 3, Kenneth E. Hastings 3, Simon S. Wing 2 1 Department of Biochemistry, McGill University, Montreal, QC, Canada; 2 Department of Medicine, McGill University, Montreal, QC, Canada; 3 Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada Background and aims : Although many enzymes involved in ubiquitination are activated in atrophying muscle, little is known about the role of deubiquitinating enzymes (DUBs)."