IndraLab

Statements

MAP3K7 binds OTUD4. 4 / 4
| 4
sparser
"OTUD4 bound TAK1 directly and coimmunoprecipitated with TAB1 and TAB3 ( xref , A–C , and J )."
41062071
sparser
"To confirm the physiological relevance of this interaction, we showed that endogenous OTUD4 and TAK1 associate in H1299 NSCLC cells ( xref , G and H ) and significantly colocalize in the cytoplasm (Pearson's correlation coefficient [PCC] = 0.66 ± 0.15; xref I )."
41062071
sparser
"Reciprocal co-IP confirmed this OTUD4–TAK1 association ( xref B )."
41062071
sparser
"To determine the functional consequence of the OTUD4–TAK1 interaction on downstream signaling, we stimulated WT (WT, OTUD4 +/+ ) and OTUD4-knockout (OTUD4 −/− ) mouse embryonic fibroblasts (MEFs) with TNF."
41062071