IndraLab

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Modified KCNK2 decreases the amount of BDNF. 3 / 3
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"As demonstrated in XREF_FIG, Plenti-TREK-1-GFP infection significantly increased TREK-1 expression in astrocytes compared with Plenti-sham-GFP infection cells (P < 0.05), and TREK-1 overexpression exhibited similar effects to the isoflurane dependent changes in the expression of BDNF, Bax and caspase-3, as TREK-1 overexpression reduced the expression of BDNF, and increased the expression of Bax and caspase-3, which was also observed for isoflurane treatment in XREF_FIG."
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"However, TREK-1 overexpression in astrocytes significantly downregulated BDNF expression, and upregulated Bax and caspase-3 expression."
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"XREF_FIG, we found that the knockdown of TREK-1 increased BDNF expression and that the over-expression of TREK-1 decreased the level of BDNF with increasing doses of isoflurane."
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