IndraLab

Statements

USP44 increases the amount of FOXP3. 4 / 4
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"Our current findings suggest that USP44, another DUB without an appreciated immunoregulatory role, can act as a distinct force to support FOXP3 expression and both Treg phenotype and function."
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"USP44 knockdown in Tregs decreased FOXP3 expression and disrupted patterns of Treg gene expression (i.e., suppression of IL-2 expression)."
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"Our present findings suggest that targeting factors such as USP44 and USP7 that promote FOXP3 expression at the protein level is a strategy that offers exciting possibilities for the fine tuning of immune responses in cancer."
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"The ability of USP44 to promote FOXP3 expression was evident in our assessment of iTreg induction under limiting TGF-beta levels."
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