IndraLab
Statements
reach
"The local conformation model emerges out of the previously published observation that the mutant CaM EF12 (where the N-lobe does not bind Ca 2+) is able to inhibit the hEAG1 channel, although with reduced potency : wild-type CaM at 270 nM reduced channel current to ~ 9%, while CaM-EF12 at a 4x higher concentration reduced the current to ~ 30%."
reach
"It was also shown that the mutant CaM EF12, i.e. a CaM in which the N-lobe EF hands 1 and 2 no not bind Ca 2+, is able to inhibit the hEAG1 channel, albeit with reduced potency, while the C-lobe mutant CaM EF34 (no Ca 2+ binding at the C-lobe) does not inhibit the channel even at a concentration of 1 muM."