IndraLab

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USP19 inhibits cell differentiation. 14 / 14
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"USP19-ER inhibited both muscle cell differentiation and the unfolded protein response gene CHOP that occurs during differentiation."
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"Consistent with these findings, a deubiquitinase USP19 suppressed pTh17 differentiation in vitro as well as Th17-mediated pathogenesis in murine autoimmune models."
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"Consistent with these findings, the deubiquitinase USP19 suppressed pTh17 differentiation in vitro as well as Th17-mediated pathogenesis in vivo."
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"Consistent with this finding, the deubiquitinase USP19 was shown to suppress pTh17 differentiation in vitro and Th17-mediated pathogenesis in vivo."
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"USP19 can inhibit myogenic differentiation through suppression of an unfolded protein response that is required for muscle cell fusion xref ."
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"These results suggested that USP19 inhibits muscle cell differentiation by suppressing the differentiation dependent induction of the UPR during myogenesis."
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"USP19 can inhibit myogenic differentiation through suppression of an unfolded protein response that is required for muscle cell fusion 74."
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"These results suggested that USP19 inhibits muscle cell differentiation by suppressing the differentiation-dependent induction of the UPR during myogenesis."
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"Because USP19 inhibits differentiation, it was somewhat surprising to observe its induction during differentiation."
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"In the case of USP19, we have also provided evidence that this modulation of UPR signaling may also occur in vivo during myogenic regeneration in response to muscle injury and that loss of USP19 can lead to a more rapid differentiation and larger myofibers (XREF_FIG)."
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"Consistent with this, our recent studies also demonstrate that overexpression of USP19 can impair muscle cell differentiation in vitro (unpublished data)."
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"USP19 deubiquitinating enzyme inhibits muscle cell differentiation by suppressing unfolded protein response signaling."
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"USP19 selectively suppresses pTh17 cell differentiation in vitro.."
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"Because USP19 inhibits differentiation, it was somewhat surprising to observe its induction during differentiation."
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