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USP44 deubiquitinates AXIN1. 3 / 3
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"<span class="match term0">USP44</span> suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating Wnt/beta-catenin pathway via <span class="match term1">Axin1</span> deubiquitination"
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"This indicates that USP44 deubiquitination of Axin1 increases beta-catenin degradation, inhibits Wnt and beta-catenin signaling, and affects CRC [XREF_BIBR]."
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"USP44, for instance, reduces AXIN1 ubiquitination to inhibit colorectal cancer cell proliferation [70]."
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