IndraLab

Statements

USP1 inhibits Genomic Instability. 4 / 4
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"Controlling the ubiquitylation of these two key players appears to be essential for proper replication fork maintenance, as loss of USP1 causes high levels of genome instability and mutagenesis."
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"However, in FA pathway, disruption of USP1 gene causes accumulation of the monoubiquitinated forms of FANCD2 and FANCI but increases ICL hypersensitivity and genomic instability [XREF_BIBR, XREF_BIBR]."
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"However, in addition to this opposition to activate and monoubiquitinate FANCD2/I, USP1 deubiquitination of FANCI has also been associated with promoting core complex recruitment to the site of DNA da[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We moreover show that loss of USP1 also suppresses DSB formation upon ssDNA gap accumulation conditions, further demonstrating that gap protection during replication is essential for genomic stability."
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