IndraLab

Statements

Flecainide inhibits SCN5A. 4 / 4
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"The drug flecainide prevents arrhythmia in humans and mouse models of CPVT by blocking NaV1.5 and RYR2 channels."
34767014
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"Flecainide further reduced theta ' max in the Scn5a +/- RV epicardium (from 0.05 (0.01) to 0.03 (0.028) ms -1; U = 18.0, P = 0.026, r = 0.54)."
23836691
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"Flecainide reduced the BCD ' in the Scn5a +/- RV epicardium (from 3.42 (0.77) to 2.66 (0.82); U = 20.0, P = 0.030, r = 0.48)."
23836691
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"The antiarrhythmic drug flecainide blocks the Nav1.5 sodium channel in the heart, slowing conduction of cardiac electrical impulse (Investigators, 1989)."
26827603